The future resolution of the structures of virulence-
related proteins and their complexes with antibodies or
ligands will provide new insights into SS2 pathogenesis. It
will also establish the basis for rationale design of small-
molecule therapeutic drugs that could be useful to prevent
or antagonize the adherence, virulence or growth of SS2
strains. The recently-resolved crystal structures of two SS2
enzymes may serve as a model for structure-based drug
design for targeting SS2 central metabolism [69,70].
Finally, the identi?cation of protective antigens seems a
promising strategy for developing engineered subunit
vaccines that might be safer than the conventional, inac-
tivated SS2 vaccine used in the swine industry. In particu-
lar, tandem fusion expression of poly-protective antigens
could result in a robust multiple-subunit vaccine candi-
date. For this purpose, it is necessary to screen SS2 surface
proteins in search for possible protective antigens
[46,49,58]. Nevertheless, searching for a naturally aviru-
lent SS2 strain and evaluating its safety and ef?cacy as an
improved alive vaccine candidate will also be an appealing
challenge. The use of mouse or swine infection models will
allow further study of the interplay between SS2 and its
host cells. Hopefully, upcoming multidisciplinary research
will provide us, in the coming years, with effective tools for
better prevention and treatment of STSS caused by SS2.
希望哪位同专业的大虾支持一下，万分感谢
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