Compound 5a: Yield 72.1% of oil; 1H NMR (300 MHz, CDCl3) ?7.70-7.74 (m, 2H, 3-Ph-2,6-2H), 7.46-7.52 (m, 3H, Ph-6-H+3-Ph-3,5-2H), 7.34-7.37 (m, 2H, Ph-3,5-2H), 7.27-7.29 (m, 1H, 3-Ph-4-H), 7.24-7.25 (m, 1H, Ph-4-H), 5.79 (s, 1H, Py-4-H), 5.02 (s, 2H, CH 2), 4.06 (s, 3H, OCH 3), 3.85 (s, 3H, CO 2CH 3), 3.69 (s, 3H, NCH 3); Anal. Calcd for: C, 66.48; H, 5.58; N, 11.08; Found: C, 66.19; H, 5.67; N, 10.99.
Compound5b:Yield68.7%ofawhitesolid,m.p.102-105 oC; 1HNMR(300MHz,CDCl3) ?7.61-7.66(m,2H, 3-Ph-2,6-2H),7.55-7.57(m,1H, Ph-6-H),7.38-7.43 (m,2H, 3-Ph-3,5-2H), 7.30-7.33 (m, 2H, Ph-3,5-2H), 7.23-7.25 (m, 1H, Ph-4-H), 5.75 (s, 1H, Py-4-H), 5.02 (s, 2H, CH 2), 4.05 (s, 3H, OCH 3), 3.85 (s, 3H, CO 2CH3), 3.68 (s, 3H, NCH 3); Anal. Calcd for: C, 60.95; H, 4.87; N, 10.15; Found: C, 61.04; H, 4.76; N, 10.12.
Compound5c:Yield75.0%ofawhitesolid,m.p.86-88 oC; 1HNMR(300MHz,CDCl3) ?7.60-7.63 (d, J=7.5H Z, 1H, Ph-6-H), 7.40-7.46 (m, 4H, Ph-3,5-2H+ 3-Ph-2,6-2H), 7.18-7.23 (m, 3H, 3-Ph-3,5-2H+Ph-4-H), 5.65 (s, 1H, Py-4-H), 5.15 (s, 2H, CH 2), 4.04 (s, 3H, NOCH 3), 3.86 (s, 3H, CO 2CH 3), 3.73 (s, 3H, NCH 3), 1.37 (s, 9H, t-Bu); Anal. Calcd for: C, 68.95; H, 6.71; N, 9.65; Found: C, 68.78; H, 6.77; N, 9.60.
Compound 5d: Yield 69.4% of a white solid, m.p. 117-118 oC; IR(KBr)_: 2930 (s, C-H), 1730 (s, C=O),1550(w,aromaticrings),1520(s,C=N),1450(s,CH 3),1220(m,C-N),770,750(s, Ph-H)cm-1;1H NMR (300 MHz, CDCl3) _7.52-7.57 (m, 2H, Ph-6-H+3-Ph-2-H), 7.42-7.46 (m, 3H, Ph-3,5-2H+3-Ph-6-H), 7.22-7.25 (m, 1H, Ph-4-H), 7.11-7.14 (d, J=8.1H Z, 1H, 3-Ph-5-H), 5.75 (s, 1H,Py-4-H),5.00(s,2H,CH 2),4.05(s,3H,NOCH3),3.84(s,3H,CO 2CH 3),3.67(s,3H, NCH 3), 2.28 (s, 3H, 3-CH 3), 2.26 (s, 3H, 4-CH 3).
Compound5e:Yield70.3%ofoil; 1HNMR(300MHz,CDCl3)7.60-7.63(d,1H,J=7.2H Z, Ph-6-H), 7.40-7.44 (m, 2H, Ph-3,5-2H), 7.19 (m, 1H, Ph-4-H), 7.03-7.10 (m, 3H, 3-Ph-3,5,6-3H), 5.55 (s, 1H, Py-4-H), 5.08 (s, 2H, CH 2), 4.04 (s, 3H, NOCH 3), 3.84 (s, 3H, CO 2CH 3), 3.48 (s, 3H, CH 3), 2.36 (s, 3H, 2-CH 3), 2.15 (s, 3H, 4-CH 3); Found: C, 67.66; H, 6.12; N, 10.28. Anal. Calcd for: C, 67.80; H, 6.18; N, 10.31;
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