As if there weren’t enough of them in the world already, scientists have succeeded in cloning flies. The alike fruit flies are the first insects ever cloned, says the Canadian team that created them. The question everyone asks is why anyone would want to clone flies in the first place. She hopes that the insects , which are very easy to experiment with , will help to adjust the cloning process in other animals and even in humans, where the technique is being researched to aid production of therapeutic (治疗的) stem cells.
In cloning, the DNA-containing nucleus of an adult cell is injected into an egg whose own nucleus(细胞核) has been removed. At the moment, the majority of cloned mice, sheep and other animals die before birth. It is thought this is because the adult DNA is not properly ‘reprogrammed’.
Using flies, researchers might discover genes that are important for this reprogramming, and that have matches in other animals. That is because it is relatively easy in flies to knock out the function of a single gene and then attempt cloning with these cells, which will test whether that gene is important. If such genes are confirmed, then in theory cloned mammalian embryos(晶胚) might be grown in selected solutions that change the activity of those genes to improve the technique’s success rate. Although some groups have attempted to clone insects before, Lloyd says this is the first time it has been successful. The team used a slight difference on the standard cloning process: they transferred nuclei taken from embryos rather than fully-grown adult cells. They sucked several nuclei (pl)out of developing fly embryos, and injected them into a fertilized(已受精的) fly egg. From over 800 early attempts, they cloned five adult insects, the group reports in the journal Genetics.
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